Air travel is a common means of transportation in Alaska. While Anchorage, which is 5-6 hours from our place, is the closest international airport, Homer and just about every other little town has an airport. There are airfields in lots of places since there are so many pilots who fly up here. Water airports are very common too.
The Alaska Railroad goes up to Denali (known as Mt. McKinley to the uninitiated) and I think Fairbanks. It also goes south of Anchorage to the Portage Glacier. Beyond that I think there is only roads.
Many people fly up here and rent RVs or cars. RVs are nice so that one can save on the expense of hotels (which might also be full) and meals in restaurants (which adds up anywhere, but more so in Alaska). Some people also take a boat out of Seward, choosing the inside or outside passage down to Seattle.